Category: Pharmaceutical/Biologics , Bioforum International
Protein structure: a Basis for Developing Protein Therapeutic Drugs
Lecturer: Mr. David Carr
Date: May 22, 2006
Location:  Kfar Maccabiah, Ramat Gan
Course Language: Hebrew
Duration: 1 - Day Course
Hours: 09:00 – 13:30, including 12:30 – 13:30 - Lunch
Price: 950 NIS + VAT
Credit Points: 0
SKU: 1
Protein structure: a Basis for Developing Protein Therapeutic Drugs
 
 
Participants of the 3-day course "The Analysis and Characterization
of Protein Therapeutic Drug", Feb. 14-16, 2006, by David Carr, are welcome to join this half-day course with no additional cost

This half-day seminar presents the basic concepts of protein structure and function
Benefits to the Participants
Participants will have an opportunity to learn modern state of HPLC mechanism and theory. The effects of adsorbent geometry, porosity and surface chemistry on the analyte retention will be explained in the direct connection with the chromatographic behavior of the eluent components and eluent pH. Systematic and fundamentally based approach to HPLC method development will allow participants significantly increase their productivity.
Issues to be covered
  • Amino acids;
    The peptide bond, side chains in protein structure and function
  • Secondary structure:
    The two main types
  • Interactions:
    Forming and stabilizing polypeptide chains, their roles in protein structure
  • Tertiary structure:
    Its role in biological activity
  • Quaternary structure
  • The structure and nature of antibodies
  • Interactions of proteins
  • Publically available protein databases
Who should attend
  • Scientists who are unfamiliar with the basic structure and functions of proteins and who are or will be working with proteins either in the field of protein therapeutics or in the field of proteomics
  • Scientists wishing to review and refresh previous knowledge or experience with proteins
  • Administrators, project managers, QA personnel, analytical chemists

    Credit points: ½ point
   
David C Carr
Since 1971 David was involved in the development of many early applications in the field of high performance liquid chromatography and was on the project team for development of the first commercial variable wavelength detector. He assumed the position of Technical Manager at Vydac, a company specializing in columns for the separation and purification of proteins and peptides, in 1984. He worked with and supported many of the early biotechnology companies such as Genentech, Amgen and Immunex in the development of analytical methods for protein analysis and characterization. He also helped develop large scale purification techniques for some early protein therapeutic drugs. While at Vydac, David authored the very popular Handbook of Analysis and Purification of Peptides and Proteins by Reversed-phase HPLC, a small monograph of widespread use in the biotechnology industry. David is very familiar with capillary electrophoresis and mass spectrometry as applied to the analysis of polypeptides. Dave has provided instruction on HPLC and the use of HPLC in the analysis and characterization of polypeptides for many years.
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