The role of Proteomics in the research of Diseases & in Drug Discovery

Lecturer: Mr. David Carr

Date: May 22, 2006
Location: Kfar Maccabiah, Ramat Gan
General Information
Duration: 1 - Day Course
Hours: 12:30 – 17:00, including 12:30 – 13:30 - Lunch
Price: 950 NIS + VAT
Credit Points: 0
SKU: 1
Course Language: Hebrew
About the Course

This seminar introduces the purposes and goals of proteomic analysis and the technologies currently used to isolate and identify cellular proteins in order to understand disease states, identify disease markers and discover targets for therapeutic drugs.
This course will briefly present the basis for the study of cellular proteins, current methodologies for such studies and the concept of protein expression levels as indicators of disease states and the effect of therapeutic drugs.
Who should attend
  • Scientist desiring to become familiar with the relatively new field of proteomics
  • Scientists involved in drug discovery or development who wish to understand what proteomics is and how it supports the drug discovery process
  • Managers, administrators and coworkers who deal with scientists working in proteins studies or drug discovery who want a brief introduction to the field
The role of Proteomics in the research of Diseases & in Drug Discovery
Benefits to the Participants
Although cellular proteins have been studied for very many years, recent technological developments in chromatography, electrophoresis and mass spectrometry have greatly accelerated the rate at which the proteins in a cell can be studied. This rapid development has, in part, been motivated by the sequencing of the human genome and the realization of the potential benefit in understanding disease states, developing drug targets and identifying disease biomarkers. 
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Issues to be covered
An introduction to the field of proteomics:
Goals and purposes of proteomic analysis of cellular proteins, including a discussion of biochemical pathways and how disease states affect protein expression. This section defines proteomic terms such as "up-regulation" and "down-regulation" and explains target proteins and drug interactions
* Post-translational modifications and their significance in proteomics:
Changes that occur to proteins after they are initially made play very important roles in their cellular functions and in cellular regulation: what post-translation modifications are and how they may affect cellular functions
* Primary approaches to proteomic analysis:
The use of gel electrophoresis and chromatography for fractionation of proteins or peptides prior to protein identification, the use of mass spectrometry with either electrospray or MALDI ion sources together with various mass analyzer platforms, comparison of different approaches, protein identification by means of computer database searching
* Measurement of relative and absolute protein concentrations:
Current techniques to quantitate proteins as a means of identifying changes that occur in protein expression as a result of disease states or drug therapies
* Examples of proteomic analysis:
Projects to identify all the proteins in specific cells or physiological samples, "targeted" proteomic studies designed to identify targets or pathways of specific disease states
About The Lecturer

Mr. David C. Carr

David Carr is a graduate of the University of California, Berkeley and did graduate work at the University of California, San Diego, in biochemistry and molecular biology. He began working in the field of High Performance Liquid Chromatography (HPLC) in 1971 at Varian Associates, a pioneer in this field. In this role he developed many early applications of this technique and was involved in the development of the first variable wavelength HPLC detector and an early fluorescence detector.
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